Nucleotide sequence of the envelope gene of Friend murine leukemia virus
نویسندگان
چکیده
منابع مشابه
Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection.
Retrovirus infection is initiated by receptor-dependent fusion of the envelope to the cell membrane. The modular organization of the envelope protein of C type retroviruses has been exploited to investigate how binding of the surface subunit (SU) to receptor triggers fusion mediated by the transmembrane (TM) subunit. We show that deletion of the receptor-binding domain (RBD) from SU of Friend m...
متن کاملIdentification of a receptor-binding pocket on the envelope protein of friend murine leukemia virus.
Based on previous structural and functional studies, a potential receptor-binding site composed of residues that form a pocket at one end of the two long antiparallel helices in the receptor-binding domain of Friend 57 murine leukemia virus envelope protein (RBD) has been proposed. To test this hypothesis, directed substitutions for residues in the pocket were introduced and consequences for in...
متن کاملMutational analysis of N-linked glycosylation sites of Friend murine leukemia virus envelope protein.
The roles played by the N-linked glycans of the Friend murine leukemia virus envelope proteins were investigated by site-specific mutagenesis. The surface protein gp70 has eight potential attachment sites for N-linked glycan; each signal asparagine was converted to aspartate, and mutant viruses were tested for the ability to grow in NIH 3T3 fibroblasts. Seven of the mutations did not affect vir...
متن کاملA new gene that controls the type of leukemia induced by Friend murine leukemia virus
NB tropic Friend murine leukemia virus (F-MuLV) replicates equally well in BALB/c and C57BL mice inoculated as neonates but causes almost exclusively erythroblastosis in BALB/c mice and nonerythroid (lymphoid and myelogenous) leukemias in C57BL mice. The C57BL resistance to erythroblastosis appears to be controlled by a single dominant gene in first and second backcrosses to BALB/c. This resist...
متن کاملSuppression of rat bone marrow cells by Friend murine leukemia virus envelope proteins.
In a retroviral rat model, we have investigated the nontransforming effects of murine leukemia virus FB29 on the bone marrow. Upon intraperitoneal inoculation with murine leukemia virus FB29 of either neonatal or adult rats, bone marrow cells became massively infected within the first 12 days postinoculation. In neonatally inoculated rats, a persistent productive bone marrow infection was estab...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1983
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.45.1.1-9.1983